Grand Canyon University – NUR 550 Topic 1 DQ 1 Identify the different levels of translational research

Grand Canyon University – NUR 550 Topic 1 DQ 1 Identify the different levels of translational research Assignment

Grand Canyon University – NUR 550 Topic 1 DQ 1 Identify the different levels of translational research Discussion

NUR–550: Translational Research and Population Health Management – Grand Canyon University Total Credits: 4

Clinical research in the form of translational research first appeared around the year 1993. (Rubio and colleagues, 2010) As a result, this method of investigation is relatively new in terms of research. There is no precise definition of translational research, but it essentially refers to two areas of translation: the adoption of community best practices and their cost-effectiveness, as well as the information gathered in pre-clinical studies and lab research (Rubio et al, 2010). Translational research is divided into three tiers, beginning with T1 and including lab research, observational research, and phase I and II clinical trials. T1 refers to the initial study or development of an intervention (Translational Research, n.d.). T2, or “translation to patients,” entails assessing the effectiveness of these interventions in a patient population, including through phase III clinical trials, researching how these new interventions interact with disease processes, and developing new recommendations based on the most recent data (Translational Research, n.d.). T3, the third phase, entails incorporating all research findings into daily practice and translating research findings into evidence-based procedures for the entire profession (Translational Research, n.d.).

According to this data, there is no distinction between translational research and evidence-based practice; rather, it serves as a means of achieving the latter. The next stage is to use all of this knowledge into evidence-based practice by following the “three T’s”. As the natural progression of translational practice ends with practice, this means the most recent treatment and knowledge for the field of public health. However, the public will suffer if no study is done in the area because there won’t be any current EPB regarding the disease process and/or its co-morbidities.

Identify the different levels of translational research. Explain how translational research is different from evidence-based practice and discuss application to population health management.

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Re: Topic 1 DQ 1

Translational research is form of clinical research that was first seen around 1993 (Rubio et al, 2010). So as far as research goes this is a fairly new was to look into things. There is also no clear definition of translational research, but essentially it encompasses two areas of translation one being the information obtained in pre-clinical studies, lab research and the other being the adaptation of best practices in the community with their cost effectiveness (Rubio et al, 2010). There are three levels of translational research, starting with T1, which involves the beginning research or development of an intervention, including the lab research, observational research and phase I and II clinical trials (Translational Research, n.d.). The second level is T2 the translation to patients, testing these interventions and their efficacy on the patient populace, including phase III clinical trials, studying how these new interventions work with disease processes and creating new guidelines with up-to-date information (Translational Research, n.d.). The third level is T3 disseminating and implementation of all the research into daily practice, creating the research evidence found into evidence-based practices across the profession (Translational Research, n.d.).

From this information there isn’t a difference between evidence-based practice and translational research, it is just a way to get to evidence based practice. By following the ‘three T’s’, the final step is to put all of this research into practice, as evidence-based practice. For public health this means the most up to date care and information as the natural progression of translational practice ends with practice. If there is no research being done in the area however, this has a negative impact on the population, as there is not up to date EPB related to that disease process and/or its co morbidities.

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Rubio, D. M., Schoenbaum, E. E., Lee, L. S., Schteingart, D. E., Marantz, P. R., Anderson, K. E., Platt, L. D., Baez, A., & Esposito, K. (2010). Defining translational research: implications for training. Academic medicine : journal of the Association of American Medical Colleges, 85(3), 470–475.

Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). Www.Tcrn.Unsw.Edu.

RESPOND HERE (150 W0ORDS, 2 REFERENCES)

This is insightful Sarah, translational research is form of clinical research that was first seen around 1993. So as far as research goes this is a fairly new was to look into things. Translational research refers to a form of study that seeks to produce more applicable, meaningful and valid outcomes that can directly impact human health. The main objective or purpose of the translational research is to translate essential science discoveries more quickly and efficiently into practices (Eske, 2020). Translational research has been applied frequently by different researchers to enhance research processes geared towards achieving quality treatment processes and effective patient outcomes. There are three major level of translational research including T1, T2, and T3. These levels need to be incorporated into the research processes to ensure accuracy and effective outcomes in the research processes (Woolf, 2018). Level I or T1 often involves development of interventions to ensure that the entire research processes is done effectively in line with the set objectives.

References

Woolf, S. H. (2018). The meaning of translational research and why it matters. Jama, 299(2), 211-213. https://jamanetwork.com/journals/jama/article-abstract/1149350

Eske, J. (2020, August 31). In vivo vs. in vitro: What is the difference? Medical News Today. Retrieved June 17, 2021, from https://www.medicalnewstoday.com/articles/in-vivo-vs-in-vitro

Re: Topic 1 DQ 1

Translational research is a new concept in my view of the world, it is a fairly new concept, as nurses we hear the term evidence-based practice (EBP) and research. Translational research is often thought of as EPB, Translational research is the research of EBP studies as well as the study and translation of EBP interventions into practice (Melnyk & Fineout-Overholt, 2019) Translational research is as stated it translates how EBP “translates” into practice, evidence-based practice is a guide to practice, translation science is the translation to implement the evidence-based research into practice. (Tilter, 2018). Translation research has different components to implementation of preclinical studies, phase one small clinical trials, phase 2&3 larger clinical trials, outcomes from the clinical trials, them phase 5 population outcomes research- these phases offer a “bench to bedside” continuum (Tilter, 2018).

Gaps between the availability of evidence and the placing evidence into practice has shown to partner with poor outcomes by not enabling caregivers to place the evidence into practice. (Tilter, 2018)Transitional research has shown to be beneficial in-patient outcomes and health care management by translating the evidence into practice which improves patient outcomes by the utilization of the evidence. In my field of Labor and delivery I have seen this similar process in the abundance availability of research and evidence of the increased risk of hypertension in pregnancy. Yet the physicians I practice with implement in very many ways through lack of translation causing early inductions and higher risk to the infants. When implementing a new technology, evidence or practice it is important to understand the research and evidence behind it as well as how best to safely implement into practice. (Sung et al., 2020) Translation research is an exciting and has multiple opportunities to advance patient outcomes, as an upcoming APRN in a magnet hospital, utilizing this process with EBP will strongly improve patient care as well as nursing practice.

References

Melnyk, B. M., PhD, RN. APRN-CNP, FAANP, FNAP, FAAN, & Fineout-Overholt, E., PhD, RN, FNAP, FAAN. (2019). Evidence-Based Practice in Nursing& Healthcare A Guide to Best Practice (4th ed.). Wolters Kluwer.

Sung, V. W., MD MPH, Tulikangas, P., MD, Bradley, C. S., MD, MSCE, & Rideway, B., MD. (2020). Assessing and adopting New medical devices for Obstetric and Gynecologic care. ACOG, 135(4), 160–166. Retrieved May 26, 2021, from

Tilter, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2). Retrieved June 16, 2021, from

RESPOND HERE (150 W0ORDS, 2 REFERENCES)

This is insightful Deanna, translational research is a new concept in my view of the world, it is a fairly new concept, as nurses we hear the term evidence-based practice (EBP) and research Translational research has been applied by most researchers to influence study processes and to ensure quality outcomes in different studies (Tilter, 2018). Translational research mainly involves the production of more meaningful, and applicable results in the research process that directly benefit human health. Most researchers prefers translational research because in can be applied to enhance methodologies and general research outcomes. The application of different levels of research processes T1, T2, and T3 depend on the methodologies that have been applied as well as the research objectives (Woolf, 2018). Translation research has different components to implementation of preclinical studies, phase one small clinical trials, phase 2&3 larger clinical trials, outcomes from the clinical trials, them phase 5 population outcomes research- these phases offer a “bench to bedside” continuum.

References for the Identify the different levels of translational research essay paper

Tilter, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2). Retrieved June 16, 2021, from

Woolf, S. H. (2018). The meaning of translational research and why it matters. Jama, 299(2), 211-213. https://jamanetwork.com/journals/jama/article-abstract/1149350

Re: Topic 1 DQ 1

As nurses, we all have heard about evidence-based practice and Florence Nightingale. Although back then, the term evidence-based practice was not a common phrase, that is exactly what Florence Nightingale was doing back then. She would examine and experiment with the sanitary conditions of the facilities and look at how it affected the patient’s outcomes (Mackey & Bassendowski, 2017). Translational research is more of a newer terminology. Although it can be confused with evidence-based practice, there is a key distinction. Evidence-based practice is the act of applying the evidence into everyday practice, whereas translational research is more the act of conducting the studies to find the best evidence (Titler, 2018).

There are strict guidelines when conducting translational research or what many of us know as clinical trials. There is phase process where in order to progress to the next phase of clinical trials, they must meet certain criteria. New drugs must undergo in vitro preclinical trials where they are testing it in a laboratory setting instead of human trials. Then they can proceed to in vivo studies where they are studying it in animals and small sample size of human trials (Eske, 2020). Once it has proven to be safe, then they can progress to a phase two or three trial increasing the sample size and comparing it to common treatments or sometimes placebos. Once it has shown safety and efficacy in a phase two or three trial, it can then go for Food and Drug Administration (FDA) approval. There are also phase four and five trials that help with translating the evidence into practice and community settings (Titler, 2018).

In my specialty area of oncology, we are constantly hearing about clinical trials and new therapies coming to market. It is critical to have a good understanding of what each phase of the trial consists of and what the outcomes really mean to the patient.

References

Eske, J. (2020, August 31). In vivo vs. in vitro: What is the difference? Medical News Today. Retrieved June 17, 2021, from https://www.medicalnewstoday.com/articles/in-vivo-vs-in-vitro

Mackey, A., & Bassendowski, S. (2017). The history of evidence-based practice in nursing education and practice. Journal of Professional Nursing, 33(1), 51–55. https://doi.org/10.1016/j.profnurs.2016.05.009

Titler, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2). https://doi.org/10.3912/OJIN.Vol23No02Man01

RESPOND HERE (150 W0ORDS, 2 REFERENCES)

This is insightful Kelli, translational research is a new concept in my view of the world, it is a fairly new concept, as nurses we hear the term evidence-based practice (EBP) and research. Translational research is critical in the research processes as they involve translation of what have been found in other studies (Eske, 2020). Most researcher prefer to apply translational research processes to influence different study outcomes. The application of different levels of research processes T1, T2, and T3 depend on the methodologies that have been applied as well as the research objectives. Translational research is a new concept in my view of the world, it is a fairly new concept, as nurses we hear the term evidence-based practice (EBP) and research (Woolf, 2018). There are three major components of translation research including T1, T2, and T3. These translational research are important in ensuring that every study outcomes are done in line with the research objectives.